Ketone bodies play a crucial role in regulating cellular processes and aging, beyond just providing energy. Research from Buck Institute scientists has uncovered a direct molecular mechanism for the regulation of misfolded proteins by ketone bodies like β-hydroxybutyrate (βHB). These findings suggest that ketone bodies may have a significant impact on brain function and could be potential targets for therapeutic development in aging and Alzheimer’s disease. The study reveals that ketone bodies interact directly with damaged proteins, making them insoluble for removal from cells through autophagy. This discovery opens up new possibilities for improving brain function through metabolic regulation.
https://www.genengnews.com/topics/translational-medicine/ketone-body-role-in-regulating-misfolded-proteins-may-inform-strategies-targeting-aging-alzheimers-disease/