In this study by Noa Liscovitch-Brauer et al., they explore the phenomenon of RNA editing in cephalopods, specifically in behaviorally sophisticated coleoid cephalopods. They find that RNA editing is highly prevalent in these species, particularly in the nervous system, and affects molecules related to excitability and neuronal morphology. Interestingly, the genomic sequence surrounding editing sites is conserved, suggesting that RNA editing may confer a selective advantage. This trade-off between genome evolution and transcriptome plasticity highlights the role of RNA recoding in diversifying proteins, particularly those involved in neural function. The study also provides evidence of conserved and species-specific editing sites that impact protein function.
https://pubmed.ncbi.nlm.nih.gov/28388405/