In recent research, scientists have discovered that glial cells in the gut can sense physical forces and play a role in triggering muscular contractions. Glial cells are also suspected to be involved in gastrointestinal disorders and diseases, making them potential targets for treatments. The dysfunction of glial cells can lead to chronic autoimmune disorders and inflammatory bowel diseases. These cells also contribute to gut pain by secreting molecules that sensitize neurons, causing pain. Targeting glial cells could help alleviate some of the pain associated with inflammatory disorders of the gut. These new findings are shedding light on gastrointestinal disorders that have been difficult to understand and treat.
https://www.quantamagazine.org/in-the-guts-second-brain-key-agents-of-health-emerge-20231121