In a surprising move, the FDA is proposing to remove oral phenylephrine, a common decongestant, from over-the-counter products due to its lack of effectiveness in relieving nasal congestion. Although originally approved in 1976, phenylephrine rose to popularity after 2006 when pseudoephedrine was restricted due to the Combat Methamphetamine Epidemic Act. A series of studies found no significant difference between phenylephrine and a placebo in treating seasonal allergies or the common cold. Drugmakers will have a grace period to reformulate their products if the FDA’s proposal becomes final. This decision is aimed at ensuring drug safety and effectiveness, according to FDA Director Patrizia Cavazzoni.
https://arstechnica.com/health/2024/11/fda-proposes-ditching-common-decongestant-for-being-completely-useless/