Summary: Perkins Tractors were used as placebos in the 18th century and demonstrated the placebo effect for the first time. Different types of placebos have varying effect sizes, with injections being more effective than pills. Physician characteristics also play a role in the effectiveness of placebos. The placebo effect has become stronger over time in the United States, impacting drug approvals. Different factors such as age and type of placebo used can influence the effectiveness of medications. This raises questions about the reliability of clinical trials and drug efficacy. The author suggests subscribing to their newsletter for more content.
https://www.samstack.io/p/all-placebos-are-not-created-equal