Ligo presents AlphaFold3, an open-source project aimed at advancing biomolecular structure prediction. The release includes the full AlphaFold3 model with training code. The first phase focuses on single-chain protein prediction, with plans to add ligand, multimer, and nucleic acid prediction capabilities. While still in the early research phase, the project aims to create a fully open-source AlphaFold3 implementation for the biotech community. Surprising discoveries include discrepancies in AlphaFold3’s pseudocode, which the team addresses for transparency. They also prioritize model efficiency, optimizing components for speed and memory efficiency. Overall, this project invites community input and aims to contribute to the field of biomolecular structure prediction.
https://github.com/Ligo-Biosciences/AlphaFold3