Blood Transfusion and Brain Amyloidosis

In this editorial, the authors discuss the potential link between blood transfusions and the misfolding of amyloid β peptide, a primary component of senile plaques in Alzheimer’s disease and cerebral amyloid angiopathy (CAA). They highlight experimental studies dating back to 1993 that showed the development of cerebral amyloid deposition in animals after injection of exogenous amyloid β. Additionally, they mention clinical reports of early onset intracerebral hemorrhages in individuals who had received neurosurgical procedures involving cadaveric grafts. While the number of suspected iatrogenic CAA cases is currently small, it may increase as more cases are identified.

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