A-Alpha Bio is a promising biotech startup founded by two graduate students with the aim to solve the data problem in protein-protein interactions. Their method, AlphaSeq, utilizes yeast cell mating to gather protein interaction data at scale, unique to any competitors. While there are some outstanding concerns about post-translational modifications and scalability, AlphaSeq has shown potential in generating binding affinity data in high volumes. A-Alpha Bio is focusing on developing immunocytokines and molecular glues, benefitting from the high N by M interaction screens that their platform provides. Their innovative approach has the potential to revolutionize the field of protein-protein interaction studies.
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