The microbiome has a profound impact on health, with research aiming to reconstruct healthy microbiomes to combat various diseases. However, the field is facing a reproducibility crisis, with factors like circadian rhythms impacting research outcomes. A study found that the microbiome changes drastically in just a few hours, with circadian rhythms potentially having a bigger impact than diet. The interplay between diet, circadian rhythms, and microbiome composition is complex and important to consider in research. Researchers recommend guidelines for studying microbiomes, acknowledging the challenges of collecting data over time, especially in human subjects.
https://www.statnews.com/2024/07/01/microbiome-composition-varies-based-on-sampling-time-mouse-study-finds/