The author, Sarah Constantin, discusses the concept of “More Dakka” in medicine, where increasing the dose or intensity of a treatment can lead to better outcomes despite initial failures. She provides several examples, including chemotherapy cocktails, bright light therapy for SAD, and allopurinol for gout. Constantin also mentions that thyroid hormone therapy can benefit those with subclinical hypothyroidism, and that some vitamin deficiencies may still cause symptoms even if above the official deficiency cutoff. Moreover, she explains how the use of multiple drugs in HIV treatment can prevent resistance. The author touches on the mathematical principles behind these phenomena and highlights the fascinating world of systems biology.
https://qualiacomputing.com/2019/09/06/more-dakka-in-medicine/