In this blog post, the author discusses the metaphor of the broken stair, comparing it to the way people warn others about a person’s behavior rather than addressing the issue directly. The author reflects on the broken staircase of pharmacokinetics in drug development, highlighting the complexities and limitations of current understanding. They raise the point that while the field of pharmacokinetics provides descriptive information, it lacks predictability. The author suggests that more investment and research into this area could save significant money and improve patient outcomes. However, they acknowledge that such efforts would require coordination and funding.
https://trevorklee.substack.com/p/pharmacokinetics-drug-developments