In this groundbreaking study, researchers showcase the use of a video game engine to render biological macromolecules at the atomic level within cells, providing a unique and interactive way to explore these structures in their native environment. While CryoET has allowed for high-resolution imaging of macromolecules, visualizing the complex cellular environment in real-time has been a major obstacle. The use of a video game engine offers a solution to this challenge, allowing for the navigation and exploration of millions of molecules within cells. This innovative approach opens up new possibilities for understanding cellular structures and processes. The authors have disclosed no competing interests.
https://www.biorxiv.org/content/10.1101/2023.12.08.570879v1