This study of 72,269 UK adults examined the relationship between irregular sleep patterns, measured using wrist accelerometers, and major adverse cardiovascular events (MACE) over 8 years. Irregular and moderately irregular sleepers had a higher risk of MACE compared to regular sleepers. The study found a near-linear association between sleep regularity and MACE risk, with better sleep regularity associated with lower risk. Surprisingly, meeting age-specific sleep duration recommendations did not offset MACE risk for irregular sleepers. The study suggests that sleep regularity should be considered a risk factor for cardiovascular disease in public health guidelines and clinical practice.
https://jech.bmj.com/content/early/2024/10/30/jech-2024-222795