Scientists have discovered that the protein Reelin may protect the brain from Alzheimer’s and cognitive decline. Reelin levels are linked to maintaining thinking and memory, and when they decrease, neurons become more vulnerable. Study of a Colombian man revealed a rare gene variant that enhanced Reelin’s ability to reduce brain impairments. In-depth analysis of brain samples showed those with higher Reelin-producing neurons had better cognitive function. These findings suggest that Alzheimer’s may selectively damage Reelin-producing neurons, making the brain more susceptible to disease. The breakthrough was made with the help of a Colombian family participating in research studies, highlighting the significance of gene variants like Reelin in preventing Alzheimer’s.
https://www.npr.org/sections/shots-health-news/2024/07/29/g-s1-13519/alzheimers-protein-reelin-brain-aging-amyloid-tau-memory