A recent study has found that dysregulation of certain proteins in middle age can be linked to the development of dementia later in life. The study, which followed thousands of individuals over a 25-year period, analyzed blood samples to identify predictors of dementia onset. Researchers found 32 proteins that, if dysregulated between the ages of 45 and 60, were strongly associated with an elevated chance of developing dementia. Interestingly, some of these proteins have functions unrelated to the brain, indicating that peripheral biology may play a role in the disease. Further research is needed to understand the exact mechanisms and potential for early interventions or personalized treatments.
https://www.nature.com/articles/d41586-023-02374-2